In this study, we evaluated whether voluntary exercise could alleviate oxidative stress in the heart and blood of streptozotocin induced diabetic rats. In conclusion, these results suggested that gse extract was able to improve the antioxidant defense and reduce diabetic oxidative stress and protect the kidneys against diabetic nephropathy and slow its early progression so having potential protective role. The mechanism might be that ved improves hypoxia state of penile tissues, decreases noxros oxidase pathway, and enhances the enosakt pathway, which leads to penile vascular endothelial cells and vascular smooth muscle cells repairing, as. In this study, the efficacy of achillea santolina extract in relieving the oxidative stress associated with diabetes was examined in liver of stzinduced diabetic rat model. Diabetes mellitus, selenium nanoparticles, grape seed extract, oxidative stress, vitamin c, e. Oxidative stress in diabetes mellitus article pdf available in international journal of biological chemistry 93.
Oxidative stress plays an important role in diabetes and other oxygenrelated diseases. The pressure from oxidative stress in combination with lowered antioxidant defense creates a harmful combination that disrupts functions and damage cells, which lead to loss of synapse and cell death. This study was conducted to determine the effects of p. This may result from the protective effect of insulin as anti inflammatory and the potential antioxidant properties of barley whole grain. Sulaiman 1, mohd suhaimi ab wahab 1, kuttulebbai n. Effects on parameters of mental health, biomarkers of inflammation, and oxidative stress. Pdf oxidative stress triggers cardiac fibrosis in the. Also, hyperglycemia leads to elevated oxidative stress in diabetic patients which involves extensive lipid peroxidation 40, 41. Nakhaee, alireza, bokaeian, mohammad, akbarzadeh, azim, hashemi, mohammad source. The natural rotenoid deguelin ameliorates diabetic neuropathy by. This study examined the effect of grape seed proanthocyanidin extract gspe on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. Muscle wasting in diabetic and in tumorbearing rats. Luteolin has been reported to attenuate ischemiareperfusion ir injury in the diabetic heart through endothelial nitric oxide synthase enos related antioxidative response.
Pulmonary oxidative stress in diabetic rats exposed to hyperoxia. Furthermore we investigate the curative effect of oleuropein which known to be a powerful antioxidant 11. In this study, we used an experimental dn model to investigate the molecular mechanism of rlm extract inactivat. The proximate composition of chrysophyllum albidum seed methanol extract was found to contain crude protein 8. Our data provides evidence that oxidative stress in diabetic rats may be attenuated by curcumin by inhibiting polyol pathway associated with downregulated expression of pkc and parp, as evidenced. Oxidative stress impairs skeletal muscle repair in diabetic rats manuela aragno, 1raffaella mastrocola, maria graziella catalano, 2enrico brignardello, oliviero danni,1 and giuseppe boccuzzi2 alongside increased proteolysis, the inability to repair damaged skeletal muscle is a characteristic feature of uncontrolled diabetes. Pdf immunological evidence for increased oxidative. Voluntary exercise protects heart from oxidative stress in diabetic. Propolis improves pregnancy outcomes and placental. We studied histological features of diabetes lesions and modifications in the heart and oxidative stress establishment. Luteolin attenuates cardiac ischemiareperfusion injury in. Original article inhibition of p66shcinduced oxidative. Enalapril attenuates oxidative stress in diabetic rats. The results showed that diabetic rats supplemented.
Mitochondrial dysfunction and oxidative stress play an important role in the pathogenesis of both atrial fibrillation af and diabetes mellitus dm. Aleissa,1 saad alkahtani,2 mabrouk attia abd eldaim,3 ali meawad ahmed,4 simona g. Deguelindiabetic neuropathynrf2h2s oxidative stressneuroinflammation. Effect of the combination of pioglitazone with metformin or glimepiride on the serum antioxidant status and glucose level in nastzinduced diabetic rats. Bmediated inflammation and apoptosis in the testes of streptozotocininduced diabetic rats. This experimental work was conducted on 5 groups of wistar rats. Effects of methanol extract of chrysophyllum albidum. Shin sato, a saori kataoka, a akane kimura, a yuuka mukai b. Oxidative stress as a common mediator for apoptosis. Diabetes was induced in overnight fasted rats by a single intraperitoneal injection of stz 65 mgkg body weight and nicotinamide 110 mgkg.
According to our study, lycopene intakes at experimental dosages appear to have beneficial effects on ameliorating oxidative stress and inflammation in type 2 diabetes mellitus t2dm rats, suggesting that lycopene might help improving t2dm progression when its daily intake is up to about 0. Azuki bean vigna angularis extract reduces oxidative. The effects of melatonin supplementation on parameters of. Heart histopathology and oxidative features in diabetic.
Diabetic rats were administered with 400 mgkg of aqueous extract of p. Article information, pdf download for effects of melatonin on oxidative stress in. To investigate the possible role of oxidative stress as a common mediator of apoptosis and cardiac damage in diabetes. In livers of diabetic rats, reduced concentration of nitrite and increased lipid. Effects of melatonin on oxidative stress in streptozotocininduced. Wenxin keli wxkl, an antiarrhythmic traditional chinese medicine, has been shown to prevent cardiac arrhythmias through modulation of cardiac ion channels. Attenuation of oxidative stress and cardioprotective. Also, the levels of enzymatic and nonenzymatic antioxidant parameters showed a significant decline in the brain of diabetic rats.
To evaluate the pulmonary oxidative stress in diabetic rats exposed to. Transgenic activation of the kallikreinkinin system. Role of pioglitazone with metformin or glimepiride on. However, the effect of the extract on oxidative stress during diabetes is not known. The markers of oxidative stress, antioxidant enzyme activities. In this study, we used an experimental dn model to investigate. The present study aimed to compare the modulatory effects of garlic, ginger, turmeric and their mixture on the metabolic syndrome and oxidative stress in streptozotocin stznicotinamide diabetic rats. Pdf changes in the oxidative stress biomarkers in liver. Pdf curcumin attenuates oxidative stress in liver in. Ros generation in diabetic kidneys is caused by enzymatic and nonenzymatic. Streptozotocin stz is used for medical treatment of neoplastic islet. Fifty 6weekold female wistar rats were randomly assigned to receive an injection of stz to induce diabetes n 40 or. Fucoidan ameliorates oxidative stress, inflammation, dna.
Ris procite, reference manager, endnote, bibtex, medlars. Diabetes was induced in wistar rats with streptozotocin, and groups of diabetic rats were treated wit h 5 and 10fold dietary zn interventions 0 19 and 038g znkg diet for 6 weeks. The experimental t2dm significantly p oxidative stress and blood glucose level compared to the control animals. Differential responses to blood pressure and oxidative. Pdf markers of oxidative stress during diabetes mellitus. Diabetes was induced in wistar rats with streptozotocin, and groups of diabetic rats were treated with 5 and 10fold dietary zn interventions 019 and 038 g znkg diet for 6 weeks. Whoever, many studies have showed that hyperglycaemia in diabetes responsible is for oxidative stress.
Pdf enalapril attenuates oxidative stress in diabetic. Thirty male rats were divided into three groups of 10 rats each. Diabetes mellitus is a wellrecognized cause of male sexual dysfunction and impairments of male fertility. In the present study, the alloxan induced diabetic rats are used as a type 1 models which are characte.
The increase in catalase activity in erythrocytes in diabetic rats in this study could be due to higher oxidative stress. Efficacy of a methanolic extract of adansonia digitata. Parameters related to oxidative stress were studied in rats divided into 4 groups. Though the nuclear factor erythroid 2related factor 2 nrf2 is regarded as a key endogenous factor to reduce diabetic oxidative stress, whether luteolin reduces cardiac ir injury in the diabetic heart via enhancing. The rlm extract has strong antioxidant effect in vitro 20, and reduces oxidative stress injury in diabetic rat kidneys 21, 22. The role of oxidative stress in streptozotocininduced diabetic. Pdf muscle wasting in diabetic and in tumorbearing rats. Pdf oxidative stress impairs skeletal muscle repair in. Immunological evidence for increased oxidative stress in diabetic rats. Sodium tungstate attenuate oxidative stress in brain. The present study assessed the potential of zn supplementation in modulating oxidative stress and cardioprotective effects in diabetic rats. Enhancement of reactive oxygen species and induction of apoptosis. Hence, the objective of the study was to determine the effects of propolis alone or combined with insulin on maternal status, pregnancy outcomes and placental oxidative stress status in streptozotocininduced diabetic female rats.
Results obtained showed that in brain, heart and kidney tissues, the levels of malonadialdehyde, and nitric oxide showed. Psidium guajava fruit peel extract reduces oxidative. Vitamin e administration to stzinduced diabetic rats reverses oxidative imbalance and improves muscle gene transcription, reinforcing the suggestion that oxidative stress may play a role in. Azuki bean vigna angularis extract reduces oxidative stress and stimulates autophagy in the kidneys of streptozotocininduced early diabetic rats. Sirajudeen 2, md salzihan md salleh 3 and sunil gurtu 4. We found that taking melatonin by diabetic hd patients for 12 weeks resulted in a significant reduction in bdi, bai, psqi, hscrp, and mda, and a significant elevation in tac and total nitrite levels, but melatonin did not affect gsh levels. Bungau,5 bader almutairi,2 may binjumah,6 abdullah a. Pdf the role of oxidative stress in diabetic complications. Increasing evidence shows that oxidative stress is associated with the pathogenesis of diabetes, obesity, cancer, ageing, inflammation, neurodegenerative disorders, hypertension, apoptosis, cardiovascular diseases, and heart failure. Effect of the hexane extract of piper auritum on insulin. Differential responses to blood pressure and oxidative stress in streptozotocininduced diabetic wistarkyoto rats and spontaneously hypertensive rats. The results provide evidence that oxidative stress in the stzinduced diabetic rat model may be attenuated by curcumin via the activation of the. Oxidative stress and expression of insulin signaling.
In the present study, we investigated the effect of hexane, chloroform and methanol extracts from piper auritum on cell culture system and the effect in streptozotocininduced type 1 diabetic rats treated by 28 days on the physiological, metabolic parameters and oxidative stress. Wenxin keli regulates mitochondrial oxidative stress and. Three weeks after stz injection, the plasma glucose levels of the rats were evaluated. Diabetic rats treated with vitamin e giv in which observed a significant decrease in the level of urea and creatinine table 3. The tested combination senpsgse mixture is more or less equally active as that of the standard tested anti diabetic drug glimepiride key words. In recent decades, oxidative stress has become a focus of interest in most biomedical disciplines and many types of clinical research. Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats. The total protein level result in a marked reduction in the serum of diabetic rats. Pdf the prevalence of diabetes mellitus is rising all over the world. Inhibition of p66shcinduced oxidative stress protects against rat diabetic retinopathy huiting yang, peng yao, ruishu li, xiaomei zhang department of ophthalmology, the first affiliated hospital, harbin medical university, harbin, heilongjiang, china. Original article renoprotective effect of grape seed. In the present study, an increase in the oxidative stress in the diabetic rats could be attributed to the exhaustion of the antioxidant enzymes in attenuating the free radicals generated during the metabolism of stz. This study tested the hypothesis that wxkl can improve atrial remodeling in diabetic.
Sodium tungstate attenuate oxidative stress in brain tissue of streptozotocininduced diabetic rats author. Fucoidan ameliorates oxidative stress, inflammation, dna damage, and hepatorenal injuries in diabetic rats intoxicated with aflatoxin b 1 mohammed s. Specific aimsin light of the possible involvement of intramyocardial inflammation in diabetic cardiomyopathy, we investigated cardiac cams expression icam1. Protective effects of nanostructures of hydrated c60. Effects of cocoa extract on glucometabolism, oxidative. Deguelindiabetic neuropathynrf2h2soxidative stressneuroinflammation.
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